Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | WNT3A | P56704 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492760 | 0.89 | CNR1 (0.66) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7964831 | 0.87 | ROCK2 (0.58) | ROCK2MAPK1PSEN1PSEN2APH1B | |
| SCHEMBL2183597 | 0.84 | PSEN1 (0.79) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492812 | 0.83 | MAPK1 (0.62) | ROCK2MAPK1PSEN1PSEN2APH1B | |
| SCHEMBL1492798 | 0.79 | PSEN1 (0.72) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492962 | 0.78 | WNT3A (0.56) | ROCK2MAPK1PSEN1PSEN2APH1B | |
| SCHEMBL1492651 | 0.78 | PSEN1 (0.69) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492734 | 0.78 | PSEN1 (0.66) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492944 | 0.78 | KIT (0.61) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12650259 | 0.77 | PSEN1 (0.58) | ROCK2MAPK1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |