Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 8/20 | 0.58 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.58 |
| ▸ | ALB | P02768 | 2/20 | 0.57 |
| ▸ | WDR5 | P61964 | 1/20 | 0.57 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | SHC1 | P29353 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14932598 | 0.91 | HTRA2 (0.62) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL14932612 | 0.89 | HTRA2 (0.67) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL14932607 | 0.89 | HTRA2 (0.54) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL21730313 | 0.85 | ALB (0.59) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL16234096 | 0.83 | HTRA2 (0.65) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL14932621 | 0.83 | HTRA2 (0.65) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL20235786 | 0.83 | HTRA2 (0.64) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL20047392 | 0.82 | FOLH1 (0.51) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL14932614 | 0.82 | HTRA2 (0.52) | HTRA2HTRA1FOLH1ALBWDR5 | |
| SCHEMBL20230256 | 0.82 | WDR5 (0.56) | HTRA2HTRA1FOLH1ALBWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | THE BROAD INSTITUTE, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | BROAD INST INC (US) | 2018-06-07 | — | — | US | disclosed |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2014-11-13 | — | — | US | disclosed |
| WO-2013067391-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | KDM1A, MAN2B1, KDM3A | HTRA2 3856/4885HTRA1 1400/4885FOLH1 814/4885 |
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | KDM1A, MAN2B1, KDM3A | HTRA2 3856/4885HTRA1 1400/4885FOLH1 814/4885 |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | MAN2B1, KDM1A, KDM3A | HTRA2 3894/4885HTRA1 1291/4885FOLH1 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.