Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | HTRA2 | O43464 | 8/20 | 0.51 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.51 |
| ▸ | ALB | P02768 | 2/20 | 0.50 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19967086 | 0.94 | FOLH1 (0.50) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932607 | 0.93 | HTRA2 (0.54) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932614 | 0.87 | HTRA2 (0.52) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL20235786 | 0.86 | HTRA2 (0.64) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL20235710 | 0.86 | HTRA2 (0.49) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932664 | 0.82 | HTRA2 (0.58) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932598 | 0.79 | HTRA2 (0.62) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932612 | 0.79 | HTRA2 (0.67) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL13833492 | 0.77 | HTRA2 (0.38) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL18220761 | 0.74 | HTRA2 (0.35) | FOLH1HTRA2HTRA1ALBWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | BROAD INST INC (US) | 2018-06-07 | — | — | US | disclosed |
| US-20180099977-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE, INC. (US) | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099977-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC11 | FOLH1 3742/4885HTRA2 2080/4885HTRA1 558/4885 |
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | KDM1A, MAN2B1, KDM3A | FOLH1 814/4885HTRA2 3856/4885HTRA1 1400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.