Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 3/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490950 | 0.87 | LMNA (0.39) | LMNAFABP4BRAFMEN1MAPT | |
| SCHEMBL1490997 | 0.74 | PSEN1 (0.35) | LMNABRAFMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1592968 | 0.74 | ESR1 (0.38) | LMNAFABP4SMN1; SMN2 | |
| SCHEMBL1490948 | 0.72 | BRAF (0.55) | FABP4BRAFMETAP2 | |
| SCHEMBL1493315 | 0.72 | FABP4 (0.47) | FABP4BRAFMETAP2 | |
| SCHEMBL27838929 | 0.71 | MCL1 (0.38) | FABP4ALDH1A1 | |
| SCHEMBL8001344 | 0.70 | BRAF (0.34) | LMNAFABP4BRAFMETAP2 | |
| SCHEMBL3529771 | 0.70 | FABP4 (0.53) | FABP4BRAFMAPTKMT2AMETAP2 | |
| SCHEMBL1437491 | 0.69 | AKR1B1 (0.34) | LMNAFABP4BRAF | |
| SCHEMBL27838901 | 0.69 | NR1I2 (0.38) | MAPTKEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470539-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025951-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |