Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14933289 | 0.95 | CYP2D6 (0.30) | CYP2D6CYP2C19 | |
| SCHEMBL14933288 | 0.87 | — | — | |
| SCHEMBL12506431 | 0.57 | CYP2D6 (0.34) | CYP2D6CYP2C19 | |
| SCHEMBL1684927 | 0.57 | — | — | |
| SCHEMBL3285840 | 0.47 | NLRP3 (0.33) | — | |
| SCHEMBL28392433 | 0.47 | NLRP3 (0.33) | — | |
| SCHEMBL9318483 | 0.46 | CA2 (0.32) | — | |
| SCHEMBL3289507 | 0.46 | NLRP3 (0.32) | — | |
| SCHEMBL9452647 | 0.46 | — | — | |
| SCHEMBL4365635 | 0.46 | MEN1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288185-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS | TARGACEPT, INC. | 2014-09-25 | — | — | US | disclosed |
| WO-2013067105-A2 | NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS | TARGACEPT, INC. (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288185-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS | CHRNA5, CHRNG, CHRNA2 | CYP2D6 1959/4885CYP2C19 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.