Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16335478 | 0.87 | NOTUM (0.76) | NOTUMMAPTMRGPRX4CA12CA1 | |
| SCHEMBL15670215 | 0.84 | CA12 (0.51) | NOTUMMAPTCA12CA1CA2 | |
| SCHEMBL14317068 | 0.84 | MAPT (0.64) | NOTUMMGLLMAPTMRGPRX4CA12 | |
| SCHEMBL7354789 | 0.84 | XDH (0.59) | NOTUMMAPTMRGPRX4CA12CA1 | |
| SCHEMBL8383581 | 0.83 | EPHX2 (0.44) | NOTUMALDH1A1KMT2APDK2L3MBTL1 | |
| SCHEMBL2590647 | 0.83 | RAB9A (0.49) | NOTUMMRGPRX4CA12CA1CA2 | |
| SCHEMBL7361708 | 0.83 | USP2 (0.60) | NOTUMMAPTMRGPRX4CA12CA1 | |
| SCHEMBL4314290 | 0.83 | NOTUM (0.63) | NOTUMMGLLMAPTMRGPRX4CA12 | |
| SCHEMBL9712610 | 0.82 | EPHX2 (0.40) | NOTUMEPHX2 | |
| SCHEMBL16371917 | 0.82 | NOTUM (0.53) | NOTUMMGLLMAPTMRGPRX4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013064231-A1 | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) | PHENEX PHARMACEUTICALS AG (DE) | 2013-05-10 | — | — | WO | disclosed |