SCHEMBL7361708

SCHEMBL7361708

COC(=O)c1ccc(OC(F)(F)F)c(N)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.60
ALDH1A1 P00352 7/20 0.57
KDM4E B2RXH2 7/20 0.57
MAPT P10636 6/20 0.57
HPGD P15428 6/20 0.57
HSD17B10 Q99714 3/20 0.57
GAA P10253 2/20 0.57
GLA P06280 1/20 0.57
CASP1 P29466 1/20 0.57
CASP7 P55210 1/20 0.57
ATM Q13315 1/20 0.57
LMNA P02545 3/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
NOTUM Q6P988 2/20 0.50
HTT P42858 1/20 0.50
NPC1 O15118 4/20 0.47
RAB9A P51151 3/20 0.47
NPSR1 Q6W5P4 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
MRGPRX4 Q96LA9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2033666 0.88 NOTUM (0.54) USP2ALDH1A1KDM4EMAPTHPGD
SCHEMBL31003812 0.88 NOTUM (0.54) USP2ALDH1A1KDM4EMAPTHPGD
Hydrochloric Acid SCHEMBL2241815 0.86 NOTUM (0.52) USP2ALDH1A1KDM4EMAPTHPGD
SCHEMBL31615997 0.86 USP2 (0.61) USP2ALDH1A1KDM4EMAPTHPGD
SCHEMBL16098092 0.84 CYP1A2 (0.51) USP2ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL14317068 0.83 MAPT (0.64) ALDH1A1KDM4EMAPTGLAATM
SCHEMBL7354789 0.83 XDH (0.59) USP2ALDH1A1KDM4EMAPTHPGD
SCHEMBL14933935 0.83 NOTUM (0.58) USP2ALDH1A1KDM4EMAPTHPGD
SCHEMBL6112777 0.82 SLC6A2 (0.49) USP2ALDH1A1KDM4EHSD17B10LMNA
SCHEMBL2348012 0.82 RXRA (0.47) USP2ALDH1A1KDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637437-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2026-05-26 US disclosed
EP-4337651-B1 SUBSTITUTED BENZAMIDES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2026-02-04 EP disclosed
US-20260022099-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2026-01-22 US disclosed
US-12371408-B2 Aryl hydrocarbon receptor agonists and uses thereof NEXYS THERAPEUTICS, INC. (US) 2025-07-29 US disclosed
EP-4263510-B1 HERBICIDAL TETRAZOLE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-03-26 EP disclosed
US-12168646-B2 Aryl hydrocarbon receptor agonists and uses thereof NEXYS THERAPEUTICS, INC. (US) 2024-12-17 US disclosed
EP-4472953-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF Nexys Therapeutics, Inc. (US) 2024-12-11 EP disclosed
US-20240279185-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2024-08-22 US disclosed
US-20240254111-A1 SUBSTITUTED BENZAMIDES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2024-08-01 US disclosed
US-20240254094-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-08-01 US disclosed
US-6096768-A ADMINISTERING A 3, 5, 6-SUBSTITUTED PHENYL COMPOUND FOR THE TREATMENT OF INFLAMMATION AND AUTOIMMUNE DISORDERS RHONE-POULENC RORER LIMITED (GB) 2000-08-01 US disclosed
US-5935978-A Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group RHONE-POULENC RORER LIMITED (GB) 1999-08-10 US disclosed
US-5840724-A COMPOUNDS FOR TUMOR NECROSIS FACTOR OR ENZYME INHIBITORS OF PHOSPHODIESTERASES RHONE-POULENC RORER LIMITED (GB) 1998-11-24 US disclosed
EP-0741707-B1 SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS RHONE POULENC RORER LTD (GB) 1998-04-01 EP disclosed
US-5698711-A INHIBITORS OF TUMOR NECROSIS FACTOR, CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE AND EOSINOPHILS RHONE-POULENC RORER LIMITED (GB) 1997-12-16 US disclosed
US-5679696-A FOR INHIBITING TUMOR NECROSIS FACTOR; ENZYME INHIBITORS RHONE-POULENC RORER LIMITED (GB) 1997-10-21 US disclosed
EP-0741707-A1 SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS RHONE-POULENC RORER LIMITED (GB) 1996-11-13 EP disclosed
WO-1995020578-A1 SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS RHONE-POULENC RORER LIMITED (GB) 1995-08-03 WO disclosed
EP-0652868-A1 INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF RHONE-POULENC RORER LIMITED (GB) 1995-05-17 EP disclosed
WO-1994002465-A1 INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF RHONE-POULENC RORER LIMITED (GB) 1994-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240254111-A1 SUBSTITUTED BENZAMIDES AS HERBICIDES CBR3, H1-3, H1-4 USP2 1620/4885ALDH1A1 320/4885KDM4E 311/4885
US-12371408-B2 Aryl hydrocarbon receptor agonists and uses thereof AHR, ARNT, NR1H2 USP2 916/4885ALDH1A1 602/4885KDM4E 2343/4885
US-20260022099-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF AHR, NR1H4, CNR1 USP2 1283/4885ALDH1A1 807/4885KDM4E 2121/4885
US-20240254094-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 USP2 2373/4885ALDH1A1 98/4885KDM4E 476/4885
US-20240279185-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF AHR, ARNT, NR1H2 USP2 916/4885ALDH1A1 602/4885KDM4E 2343/4885
US-12637437-B2 Herbicidal compounds CBR3, CBR1, DDT USP2 3241/4885ALDH1A1 358/4885KDM4E 1892/4885
US-12168646-B2 Aryl hydrocarbon receptor agonists and uses thereof AHR, ARNT, NR1H2 USP2 916/4885ALDH1A1 602/4885KDM4E 2343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.