Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | CHKA | P35790 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320439 | 0.89 | LMNA (0.61) | HRH3HDAC6CHKALMNAMC4R | |
| SCHEMBL14934913 | 0.89 | ALDH1A1 (0.51) | HRH3AKR1C3LMNAALDH1A1HTT | |
| SCHEMBL14934955 | 0.88 | AKR1C3 (0.54) | HRH3HDAC6AKR1C3CHKALMNA | |
| Hydrochloric Acid SCHEMBL21747953 | 0.88 | LMNA (0.59) | HRH3HDAC6CHKALMNAMC4R | |
| SCHEMBL14934918 | 0.87 | HRH3 (0.54) | HRH3AKR1C3ALDH1A1 | |
| SCHEMBL14934917 | 0.84 | AKR1C3 (0.72) | HRH3AKR1C3ALDH1A1 | |
| SCHEMBL3125212 | 0.84 | HRH3 (0.71) | HRH3LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16121611 | 0.84 | CHKA (0.69) | HRH3CHKALMNAMC4RCA2 | |
| SCHEMBL28440571 | 0.82 | LMNA (0.53) | HRH3HDAC6CHKALMNAMC4R | |
| SCHEMBL14934936 | 0.82 | AKR1C3 (0.45) | HRH3AKR1C3ALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013064068-A1 | THIENOPYRIMIDINE AND FUROPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF | 上海希迈医药科技有限公司 (CN) | 2013-05-10 | — | — | WO | disclosed |