Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12411112 | 0.82 | SYK (0.50) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL18176130 | 0.75 | PIM1 (0.50) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL18013223 | 0.75 | HTR3E (0.47) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL14890705 | 0.75 | SYK (0.44) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL2412673 | 0.74 | SYK (0.45) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL2637996 | 0.72 | SYK (0.47) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL2637993 | 0.72 | SYK (0.47) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL2638109 | 0.72 | SYK (0.47) | SYKADORA2AADORA1PDK2PDK4 | |
| SCHEMBL8326245 | 0.69 | SYK (0.48) | SYKADORA2AADORA1MKNK1MKNK2 | |
| SCHEMBL8326248 | 0.69 | SYK (0.48) | SYKADORA2AADORA1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013064445-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-10 | — | — | WO | disclosed |