Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.45 |
| ▸ | ITGAL | P20701 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326245 | 1.00 | SYK (0.48) | SYKPDE10AMKNK1MKNK2ADORA2A | |
| SCHEMBL28811057 | 0.84 | CHI3L1 (0.46) | ADORA2AADORA1CHI3L1PLD1 | |
| SCHEMBL28811056 | 0.84 | CHI3L1 (0.46) | ADORA2AADORA1CHI3L1PLD1 | |
| SCHEMBL3646618 | 0.81 | CHI3L1 (0.41) | ADORA2AADORA1CHI3L1PLD1 | |
| SCHEMBL27463572 | 0.80 | ALDH1A1 (0.40) | SYKCCNE1CDK2CHI3L1 | |
| SCHEMBL27693766 | 0.80 | SORD (0.43) | SYKPDE10AMKNK1MKNK2ADORA2A | |
| SCHEMBL6354342 | 0.79 | KDM4E (0.43) | CDK4CCND1CDK2PLD1CDK1 | |
| SCHEMBL13280367 | 0.78 | ITGB2 (0.45) | SYKPDE10AMKNK1MKNK2ADORA2A | |
| SCHEMBL13280212 | 0.78 | ITGB2 (0.45) | SYKPDE10AMKNK1MKNK2ADORA2A | |
| SCHEMBL21360414 | 0.78 | PLD1 (0.54) | PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112930346-A | Novel compounds as NADPH oxidase inhibitors | 金其尤泰克斯瑞士股份有限公司 | 2021-06-08 | — | — | CN | disclosed |
| US-5919782-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-06 | — | — | US | disclosed |