Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 12/20 | 0.63 |
| ▸ | BCL2 | P10415 | 8/20 | 0.63 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14935514 | 0.87 | MCL1 (0.60) | MCL1BCL2BCL2L1ALDH1A1PRMT1 | |
| SCHEMBL14949187 | 0.81 | MCL1 (0.44) | MCL1BCL2BCL2L1ALDH1A1PRMT1 | |
| SCHEMBL15177181 | 0.79 | MCL1 (0.58) | MCL1BCL2BCL2L1ALDH1A1PRMT1 | |
| SCHEMBL14935611 | 0.78 | MCL1 (1.00) | MCL1BCL2BCL2L1 | |
| SCHEMBL14949237 | 0.78 | MCL1 (0.71) | MCL1BCL2BCL2L1 | |
| SCHEMBL14935682 | 0.78 | MCL1 (1.00) | MCL1BCL2BCL2L1 | |
| SCHEMBL1198049 | 0.77 | ADORA2A (0.50) | MCL1BCL2BCL2L1ALDH1A1PRMT1 | |
| SCHEMBL28028227 | 0.76 | MCL1 (0.44) | MCL1BCL2BCL2L1ALDH1A1PRMT1 | |
| SCHEMBL28028179 | 0.76 | LTA4H (0.44) | MCL1BCL2BCL2L1ALDH1A1PRMT1 | |
| SCHEMBL14665257 | 0.75 | CARM1 (0.50) | MCL1BCL2BCL2L1CASP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614333-B2 | Acenaphtho heterocyclic compound and application thereof | DALIAN UNIVERSITY OF TECHNOLOGY (CN) | 2013-12-24 | — | — | US | disclosed |
| US-20130123492-A1 | ACENAPHTHO HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | DALIAN UNIVERSITY OF TECHNOLOGY (CN) | 2013-05-16 | — | — | US | disclosed |
| US-20130123492-A1 | ACENAPHTHO HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | DALIAN UNIVERSITY OF TECHNOLOGY (CN) | 2013-05-16 | — | — | US | disclosed |
| US-20130123492-A1 | ACENAPHTHO HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | DALIAN UNIVERSITY OF TECHNOLOGY (CN) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123492-A1 | ACENAPHTHO HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | MCL1, BCL2L1, BCL2 | MCL1 1/4885BCL2 3/4885BCL2L1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.