SCHEMBL14936845

SCHEMBL14936845

C/C=C/C(=O)OCc1ccc(C)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.50
EGFR P00533 1/20 0.48
BTK Q06187 1/20 0.48
LMNA P02545 1/20 0.47
P2RX4 Q99571 1/20 0.46
GSTP1 P09211 1/20 0.45
MET P08581 1/20 0.44
MMP2 P08253 2/20 0.44
MMP12 P39900 2/20 0.44
MMP1 P03956 1/20 0.44
MMP9 P14780 1/20 0.44
CA9 Q16790 2/20 0.44
CA12 O43570 1/20 0.44
AKR1B10 O60218 1/20 0.44
AKR1B1 P15121 1/20 0.44
CA4 P22748 1/20 0.44
CA6 P23280 1/20 0.44
CA5A P35218 1/20 0.44
CA7 P43166 1/20 0.44
CA14 Q9ULX7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14936847 1.00 HCAR2 (0.50) HCAR2EGFRBTKLMNAP2RX4
SCHEMBL13536546 0.89 EGFR (0.42) HCAR2EGFRBTKLMNAP2RX4
SCHEMBL20211557 0.87 HCAR2 (0.51) HCAR2EGFRBTKLMNAGSTP1
SCHEMBL29063508 0.87 HCAR2 (0.51) HCAR2EGFRBTKLMNAGSTP1
SCHEMBL29284548 0.84 HCAR2 (0.49) HCAR2EGFRBTKLMNAGSTP1
SCHEMBL14936905 0.84 HCAR2 (0.49) HCAR2EGFRBTKLMNAP2RX4
SCHEMBL14936903 0.84 HCAR2 (0.49) HCAR2EGFRBTKLMNAP2RX4
SCHEMBL1070426 0.84 HCAR2 (0.71) HCAR2EGFRBTKLMNACA9
SCHEMBL1070423 0.84 HCAR2 (0.71) HCAR2EGFRBTKLMNACA9
SCHEMBL14936820 0.83 ALDH1A1 (0.51) HCAR2LMNAP2RX4METMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8822724-B2 Method for producing carboxylic acid amide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-09-02 US disclosed
EP-2599769-A1 METHOD FOR PRODUCING CARBOXYLIC ACID AMIDE Sumitomo Chemical Company Limited (JP) 2013-06-05 EP disclosed
US-20130123505-A1 METHOD FOR PRODUCING CARBOXYLIC ACID AMIDE SUMITOMO CHEMICAL COMPANY, LIMITED 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123505-A1 METHOD FOR PRODUCING CARBOXYLIC ACID AMIDE HCAR2, NAAA, FAAH2 HCAR2 1/4885EGFR 572/4885BTK 4353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.