Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 14/20 | 0.43 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493643 | 0.86 | CNR2 (0.48) | CNR2CNR1HDAC1HDAC6 | |
| SCHEMBL1493689 | 0.77 | TLR7 (0.38) | CNR2CNR1 | |
| SCHEMBL1493630 | 0.75 | AURKA (0.40) | CNR2CNR1HDAC1HDAC6KDM4E | |
| SCHEMBL1493640 | 0.75 | CNR2 (0.51) | CNR2CNR1 | |
| SCHEMBL1491875 | 0.73 | CNR2 (0.39) | CNR2CNR1HDAC1HDAC6KDM4E | |
| SCHEMBL13690656 | 0.66 | KDM4E (0.39) | CNR2CNR1HDAC1HDAC6KDM4E | |
| SCHEMBL1493624 | 0.66 | AURKA (0.42) | CNR2CNR1HDAC1HDAC6KDM4E | |
| SCHEMBL4050608 | 0.65 | CNR1 (0.52) | CNR2CNR1HDAC1HDAC6KDM4E | |
| SCHEMBL593602 | 0.65 | LMNA (0.46) | CNR2KDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL4051371 | 0.64 | CNR1 (0.51) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033225-A2 | SUBSTITUTED 3-AMINO-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | WO | claimed |
| WO-2011033225-A2 | SUBSTITUTED 3-AMINO-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | WO | disclosed |