Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | HTR7 | P34969 | 7/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.43 |
| ▸ | CPT1A | P50416 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11481661 | 0.81 | CPT1A (0.60) | DPP4SPHK2SPHK1CPT2CPT1A | |
| SCHEMBL7167933 | 0.81 | CPT1A (0.60) | DPP4SPHK2SPHK1CPT2CPT1A | |
| SCHEMBL12757985 | 0.79 | PREP (0.57) | DPP4 | |
| SCHEMBL27879394 | 0.78 | ITGB1 (0.39) | DPP4ALDH1A1 | |
| SCHEMBL756323 | 0.78 | ITGB1 (0.39) | DPP4ALDH1A1 | |
| SCHEMBL1493782 | 0.77 | OPRM1 (0.41) | — | |
| SCHEMBL2177077 | 0.76 | DPP4 (0.57) | DPP4ACESPHK2SPHK1HTR1A | |
| SCHEMBL474918 | 0.76 | DPP4 (0.57) | DPP4ACESPHK2SPHK1HTR1A | |
| SCHEMBL31324114 | 0.74 | SPHK1 (0.57) | DPP4ACESPHK2SPHK1CPT2 | |
| SCHEMBL1493731 | 0.74 | POLB (0.60) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915427-B2 | Process for producing aminoacetyl pyrrolidine carbonitrile derivative and intermediate for production thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2011-03-29 | — | — | US | disclosed |
| US-7915427-B2 | Process for producing aminoacetyl pyrrolidine carbonitrile derivative and intermediate for production thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2011-03-29 | — | — | US | disclosed |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1995237-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2008-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | CBR3, CPS1, CBR1 | DPP4 2863/4885ACE 924/4885SPHK2 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.