Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 5/20 | 0.38 |
| ▸ | CFD | P00746 | 3/20 | 0.38 |
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27879394 | 1.00 | ITGB1 (0.39) | ITGB1ITGAVCNR2DPP4CFD | |
| SCHEMBL27896298 | 0.80 | DPP4 (0.58) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL1493786 | 0.80 | DPP4 (0.58) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL1493744 | 0.78 | DPP4 (0.51) | DPP4ALDH1A1 | |
| SCHEMBL1493782 | 0.78 | OPRM1 (0.41) | CNR2MAOAMAOB | |
| SCHEMBL6167365 | 0.72 | SMN1; SMN2 (0.51) | MAOAMAOB | |
| SCHEMBL9928728 | 0.72 | SMN1; SMN2 (0.51) | MAOAMAOB | |
| SCHEMBL1150921 | 0.72 | SMN1; SMN2 (0.51) | MAOAMAOB | |
| SCHEMBL12757999 | 0.70 | PIN1 (0.40) | CNR2DPP4DPP8DPP9MAOA | |
| SCHEMBL1493709 | 0.70 | PIN1 (0.40) | CNR2DPP4DPP8DPP9MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143427-B2 | Method for producing aminoacetylpyrrolidinecarbonitrile derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-03-27 | — | — | US | disclosed |
| EP-2123636-B1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7915427-B2 | Process for producing aminoacetyl pyrrolidine carbonitrile derivative and intermediate for production thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2011-03-29 | — | — | US | disclosed |
| US-20100099892-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUTICAL CO. LTD | 2010-04-22 | — | — | US | disclosed |
| EP-2123636-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1995237-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2008-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099892-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | DPP4, DPP7, DPP8 | ITGB1 2485/4885ITGAV 1338/4885CNR2 863/4885 |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | CBR3, CPS1, CBR1 | ITGB1 3747/4885ITGAV 4567/4885CNR2 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.