Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.54 |
| ▸ | RORC | P51449 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6541884 | 0.84 | MCHR1 (0.48) | RORCKDRHRH3MCHR1ROCK2 | |
| SCHEMBL8588916 | 0.84 | HTR7 (0.50) | UTS2RRORCKDRHRH3MCHR1 | |
| SCHEMBL14937407 | 0.83 | RORC (0.56) | RORCHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL6814916 | 0.83 | RORC (0.60) | RORCKDRHRH3MCHR1ALDH1A1 | |
| SCHEMBL14937482 | 0.80 | NPC1 (0.53) | RORCGRM4ALDH1A1ESRRAMEN1 | |
| SCHEMBL14937582 | 0.79 | RORC (0.57) | RORCHDAC6GRM4ALDH1A1ESRRA | |
| SCHEMBL8592660 | 0.79 | CNR1 (0.47) | RORCHRH3MAOAMCHR1ROCK2 | |
| SCHEMBL2683208 | 0.79 | HRH3 (0.54) | KDRHRH3MCHR1ALDH1A1MEN1 | |
| SCHEMBL6814919 | 0.78 | RORC (0.54) | RORCKDRHRH3HDAC1HDAC2 | |
| SCHEMBL8389361 | 0.77 | UTS2R (0.53) | UTS2RKDRHRH3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877752-B2 | 4(1H)-quinolones having antimalarial activity with reduced chemical resistance | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | CDC25C, ABCC1, CDC25A | UTS2R 2700/4885RORC 880/4885KDR 4659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.