Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RORC | P51449 | 3/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ESRRA | P11474 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14937737 | 0.85 | POLB (0.51) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL14937917 | 0.84 | TNF (0.54) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL14937407 | 0.82 | RORC (0.56) | RORCGRM4ESRRAPOLBMEN1 | |
| SCHEMBL14544527 | 0.81 | ALDH1A1 (0.71) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL14937652 | 0.80 | UTS2R (0.54) | RORCGRM4ESRRAMEN1KMT2A | |
| SCHEMBL14937146 | 0.79 | FAAH (0.48) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14937582 | 0.78 | RORC (0.57) | RORCGRM4ESRRAMEN1KMT2A | |
| SCHEMBL17601202 | 0.76 | EGFR (0.63) | NPC1RORCGRM4RAB9ASMN1; SMN2 | |
| SCHEMBL30623172 | 0.76 | EGFR (0.63) | NPC1RORCGRM4RAB9ASMN1; SMN2 | |
| SCHEMBL9730182 | 0.75 | GRM4 (0.61) | RORCGRM4ESRRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877752-B2 | 4(1H)-quinolones having antimalarial activity with reduced chemical resistance | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | CDC25C, ABCC1, CDC25A | NPC1 2324/4885RORC 880/4885GRM4 2598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.