Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SYNJ2 | O15056 | 3/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938949 | 0.76 | FOLH1 (0.45) | ATMNPC1RAB9AFOLH1CHRNB2 | |
| SCHEMBL8447511 | 0.76 | FOLH1 (0.45) | ATMNPC1RAB9AFOLH1CHRNB2 | |
| SCHEMBL8445805 | 0.76 | FOLH1 (0.45) | ATMNPC1RAB9AFOLH1CHRNB2 | |
| SCHEMBL8448905 | 0.74 | CES2 (0.46) | ATMNPC1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL8447584 | 0.74 | CES2 (0.46) | ATMNPC1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL9836356 | 0.73 | FOLH1 (0.44) | ATMNPC1RAB9AFOLH1L3MBTL1 | |
| SCHEMBL9396820 | 0.73 | ATM (0.36) | ATMNPC1RAB9AFOLH1CHRNB2 | |
| SCHEMBL9838376 | 0.70 | CYP1A2 (0.42) | ATMNPC1RAB9ACHRNB2CHRNA5 | |
| SCHEMBL6851739 | 0.70 | RECQL (0.47) | ATMNPC1RAB9AL3MBTL1TDP1 | |
| SCHEMBL9836346 | 0.70 | TDP1 (0.46) | ATMNPC1RAB9ACHRNB2CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776414-B1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | ARATANA THERAPEUTICS NV (BE) | 2016-03-16 | — | — | EP | disclosed |
| EP-2776414-A1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | Aratana Therapeutics NV (BE) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013068042-A1 | METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES | OKAPI SCIENCES NV (BE) | 2013-05-16 | — | — | WO | disclosed |