Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 6/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590593 | 0.79 | METAP1 (0.54) | METAP1S100A4HTR2AHTR2CHTR2B | |
| SCHEMBL2484416 | 0.79 | ACHE (0.73) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL28110573 | 0.78 | METAP1 (0.54) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL6972986 | 0.78 | METAP1 (0.54) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL28857993 | 0.78 | ACHE (0.46) | ACHES100A4HTR2AHTR2CHTR2B | |
| SCHEMBL31189156 | 0.77 | METAP1 (0.58) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL15617637 | 0.74 | METAP1 (0.66) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL14339926 | 0.74 | METAP1 (0.50) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL7596678 | 0.74 | METAP1 (0.49) | METAP1ACHES100A4HTR2AHTR2C | |
| SCHEMBL15617649 | 0.73 | METAP1 (0.49) | METAP1ACHEHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |