Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | TP53 | P04637 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | PTK2B | Q14289 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27296322 | 0.77 | TP53 (0.62) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL6224151 | 0.73 | MAPT (0.57) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL27944720 | 0.73 | TP53 (0.57) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL17075123 | 0.71 | MAPT (0.54) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL29392938 | 0.71 | MAPT (0.54) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL29462549 | 0.71 | MAPT (0.56) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2358320 | 0.71 | MAPT (0.56) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL19610657 | 0.70 | MAPT (0.54) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL17729217 | 0.70 | TP53 (0.54) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL29699887 | 0.68 | CYP1A2 (0.60) | MAPTNPC1RAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |