Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939367 | 0.73 | MAPT (1.00) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27296322 | 0.68 | TP53 (0.62) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27944720 | 0.65 | TP53 (0.57) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| Quinaldine SCHEMBL10623067 | 0.63 | CYP1A2 (0.63) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12270041 | 0.63 | TGFBR1 (0.67) | NPC1RAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL29392938 | 0.62 | MAPT (0.54) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17075123 | 0.62 | MAPT (0.54) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12143644 | 0.62 | MAPT (0.50) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17729217 | 0.62 | TP53 (0.54) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29578471 | 0.61 | NCF1 (0.56) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542684-A2 | NOVEL PYRAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026306-A2 | PYRAZOLE DERIVATIVES AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |