Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939592 | 0.91 | NPSR1 (0.48) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14939390 | 0.89 | NPSR1 (0.75) | NPSR1LMNAMAPTMMP2MMP9 | |
| SCHEMBL14939159 | 0.89 | SIGMAR1 (0.47) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14939053 | 0.88 | NPSR1 (0.45) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14939280 | 0.88 | NPSR1 (0.76) | NPSR1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14938747 | 0.88 | NPSR1 (0.44) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14939945 | 0.88 | NPSR1 (0.44) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14939943 | 0.85 | NPSR1 (0.41) | NPSR1ALDH1A1MAPK1HTTLMNA | |
| SCHEMBL14940114 | 0.85 | NPSR1 (0.41) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14939707 | 0.85 | NPSR1 (0.68) | NPSR1ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |