Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 2/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939266 | 0.90 | MAPT (0.55) | MAPTNPSR1OPRL1HTR7DRD2 | |
| SCHEMBL14939190 | 0.90 | MAPT (0.57) | MAPTNPSR1OPRL1LMNAHTR7 | |
| SCHEMBL14939262 | 0.90 | NPSR1 (0.53) | MAPTNPSR1LMNAKDM4ETDP1 | |
| SCHEMBL14939138 | 0.88 | NPSR1 (0.51) | MAPTNPSR1LMNAHTR7KDM4E | |
| SCHEMBL14939675 | 0.88 | NPSR1 (0.43) | MAPTNPSR1LMNAHTR7UBE2M | |
| SCHEMBL14939270 | 0.88 | NPSR1 (0.61) | MAPTNPSR1LMNADRD2DRD4 | |
| SCHEMBL14939180 | 0.87 | NPSR1 (0.50) | MAPTNPSR1LMNAKDM4ETDP1 | |
| SCHEMBL14939168 | 0.87 | MAPT (0.53) | MAPTNPSR1LMNAHTR7DRD2 | |
| SCHEMBL14940182 | 0.86 | NPSR1 (0.45) | MAPTNPSR1LMNADRD2KDM4E | |
| SCHEMBL14939636 | 0.86 | MAPT (0.54) | MAPTNPSR1LMNAHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |