Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939190 | 0.91 | MAPT (0.57) | MAPTNPSR1CCR2LMNATNF | |
| SCHEMBL14939110 | 0.89 | NPSR1 (0.55) | MAPTNPSR1LMNATP53HTR7 | |
| SCHEMBL14940165 | 0.87 | NPSR1 (0.51) | MAPTNPSR1LMNATP53DRD2 | |
| SCHEMBL14939106 | 0.87 | NPSR1 (0.64) | MAPTNPSR1LMNATP53DRD2 | |
| SCHEMBL14939615 | 0.86 | MAPT (0.53) | MAPTNPSR1LMNATP53TNF | |
| SCHEMBL14940141 | 0.85 | NPSR1 (0.54) | MAPTNPSR1LMNATP53DRD2 | |
| SCHEMBL14939396 | 0.85 | NPSR1 (0.51) | MAPTNPSR1LMNATP53DRD2 | |
| SCHEMBL14940108 | 0.84 | MAPT (0.52) | MAPTNPSR1POLBLMNATNF | |
| SCHEMBL14940268 | 0.84 | NPSR1 (0.53) | MAPTNPSR1LMNATP53DRD2 | |
| SCHEMBL14940323 | 0.83 | TP53 (0.54) | MAPTNPSR1LMNATP53HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |