Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938939 | 0.90 | GPR119 (0.50) | GPR119USP30KDM4EPKMJAK2 | |
| SCHEMBL23587587 | 0.88 | GPR119 (0.54) | GPR119KDM4EPKM | |
| SCHEMBL31668195 | 0.88 | HDAC1 (0.43) | RORCGPR119USP30JAK2JAK1 | |
| SCHEMBL23830783 | 0.81 | USP30 (0.48) | RORCGPR119NAMPTUSP30ATM | |
| SCHEMBL25199634 | 0.81 | RORC (0.48) | RORCGPR119NAMPTUSP30ATM | |
| SCHEMBL23034196 | 0.79 | GPR119 (0.44) | RORCGPR119NAMPTUSP30ATM | |
| SCHEMBL31668194 | 0.79 | MMP13 (0.48) | GPR119JAK2JAK1 | |
| SCHEMBL29479702 | 0.78 | GPR119 (0.44) | RORCGPR119NAMPTUSP30ATM | |
| SCHEMBL23012872 | 0.78 | USP30 (0.42) | RORCGPR119NAMPTUSP30ATM | |
| SCHEMBL21381612 | 0.76 | MMP13 (0.52) | GPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |