SCHEMBL14939846

SCHEMBL14939846

CCc1cccc(C2(N3CCN(Cc4cccc(OC)c4)CC3)C(=O)c3ccccc3C2=O)n1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.52
ALDH1A1 P00352 7/20 0.49
ALDH3A1 P30838 1/20 0.49
NPSR1 Q6W5P4 1/20 0.48
KDM4E B2RXH2 5/20 0.46
GAA P10253 3/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
LMNA P02545 2/20 0.46
MAPT P10636 2/20 0.46
RECQL P46063 1/20 0.46
HTR1A P08908 1/20 0.45
DRD2 P14416 1/20 0.45
HTR2B P41595 1/20 0.45
CASP1 P29466 1/20 0.45
CASP4 P49662 1/20 0.45
CASP5 P51878 1/20 0.45
FAAH O00519 1/20 0.44
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14939051 0.90 NPSR1 (0.50) SIGMAR1NPSR1MAPTHTR1ADRD2
SCHEMBL14940447 0.88 SIGMAR1 (0.54) SIGMAR1ALDH1A1ALDH3A1NPSR1KDM4E
SCHEMBL14940461 0.88 NPSR1 (0.62) SIGMAR1ALDH1A1NPSR1GAAMEN1
SCHEMBL14940056 0.87 SIGMAR1 (0.56) SIGMAR1ALDH1A1ALDH3A1NPSR1KDM4E
SCHEMBL14939645 0.87 SIGMAR1 (0.53) SIGMAR1ALDH1A1ALDH3A1NPSR1KDM4E
SCHEMBL14939434 0.87 NPSR1 (0.51) ALDH1A1ALDH3A1NPSR1KDM4EMEN1
SCHEMBL14939086 0.87 SIGMAR1 (0.50) SIGMAR1ALDH1A1ALDH3A1NPSR1KDM4E
SCHEMBL14939834 0.86 NPSR1 (0.53) SIGMAR1ALDH1A1ALDH3A1NPSR1KDM4E
SCHEMBL14939113 0.83 NPSR1 (0.53) ALDH1A1NPSR1KDM4EMEN1KMT2A
SCHEMBL14940522 0.83 NPSR1 (0.53) SIGMAR1ALDH1A1NPSR1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO claimed
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed