Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | PRKDC | P78527 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29818672 | 0.89 | ALDH1A1 (0.65) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL697093 | 0.89 | ALDH1A1 (0.59) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL282147 | 0.89 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL24311483 | 0.89 | ALDH1A1 (0.72) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL5698339 | 0.85 | ALDH1A1 (0.81) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL1039129 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL29953159 | 0.84 | ERN1 (0.53) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL2859718 | 0.84 | PRKDC (0.58) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL5355474 | 0.84 | ERN1 (0.53) | ALDH1A1KDM4ETSHRTDP1PRKDC | |
| SCHEMBL4621361 | 0.84 | ALDH1A1 (0.48) | ALDH1A1KDM4ETSHRTDP1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109781901-A | The efficient liquid phase chromatographic analysis detection method of impurity in a kind of 3,4- dimethoxy benzaldehyde | 山东新华制药股份有限公司 | 2019-05-21 | — | — | CN | claimed |
| CN-106083653-A | The synthetic method of Ormetoprim intermediate cinnamonitrile | 江苏天和制药有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-104447574-A | Method for the synthesizing ormetoprim | SUZHOU BUYUE PHARMACEUTICAL CO LTD | 2015-03-25 | — | — | CN | claimed |
| CN-120097912-A | Quinolinone derivative and preparation method thereof | 湖南大学 | 2025-06-06 | — | — | CN | disclosed |
| US-20250066309-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2025-02-27 | — | — | US | disclosed |
| US-20250025462-A1 | METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | ROCHE PALO ALTO LLC (US) | 2025-01-23 | — | — | US | disclosed |
| US-20240158356-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2024-05-16 | — | — | US | disclosed |
| US-20230100975-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2023-03-30 | — | — | US | disclosed |
| US-20210009531-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2021-01-14 | — | — | US | disclosed |
| US-20210008071-A1 | METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | ROCHE PALO ALTO LLC (US) | 2021-01-14 | — | — | US | disclosed |
| US-20210008071-A1 | METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | ROCHE PALO ALTO LLC (US) | 2021-01-14 | — | — | US | disclosed |
| US-5219848-A | Bactericides | ICI PHARMA (FR) | 1993-06-15 | — | — | US | disclosed |
| EP-0412763-A2 | Cephalosporins, processes for their preparation, pharmaceutical compositions containing them and intermediates therefor | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |
| US-4732991-A | Substituted phthalides | HILTON DAVIS CHEMICAL CO. (US) | 1988-03-22 | — | — | US | disclosed |
| US-4595768-A | 3-(substituted phenyl)phthalides | THE HILTON-DAVIS CHEMICAL CO. (US) | 1986-06-17 | — | — | US | disclosed |
| US-4216319-A | Synthesis of 2,4-diamino-5-benzylpyrimidines using benzyl cyanoacetal intermediates | BURROUGHS WELLCOME CO. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4144263-A | Benzyl cyanoacetals | BURROUGHS WELLCOME CO. (US) | 1979-03-13 | — | — | US | disclosed |
| US-4115650-A | Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4052553-A | BACTERICIDE, ANTIMALARIAL | BURROUGHS WELLCOME CO. (US) | 1977-10-04 | — | — | US | disclosed |
| US-3950236-A | OXIDATION, ALKYL-ALKOXY-BIBENZYL COMPOUNDS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF HEALTH, EDUCATION AND WELFARE (US) | 1976-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009531-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX6, P2RX2 | ALDH1A1 2017/4885KDM4E 3345/4885TSHR 1029/4885 |
| US-20210008071-A1 | METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | P2RX3, P2RX2, P2RX1 | ALDH1A1 2230/4885KDM4E 3901/4885TSHR 533/4885 |
| US-20250066309-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX6, P2RX2 | ALDH1A1 2017/4885KDM4E 3345/4885TSHR 1029/4885 |
| US-20230100975-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX6, P2RX2 | ALDH1A1 2017/4885KDM4E 3345/4885TSHR 1029/4885 |
| US-20250025462-A1 | METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | P2RX3, P2RX2, P2RX1 | ALDH1A1 2230/4885KDM4E 3901/4885TSHR 533/4885 |
| US-20240158356-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX6, P2RX2 | ALDH1A1 2017/4885KDM4E 3345/4885TSHR 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.