Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25373432 | 0.79 | PDE4B (0.36) | — | |
| SCHEMBL25372141 | 0.79 | ALDH1A1 (0.34) | JAK2 | |
| SCHEMBL25373902 | 0.79 | MAPK14 (0.33) | EGFR | |
| SCHEMBL25373360 | 0.76 | GAA (0.41) | JAK2 | |
| SCHEMBL18367335 | 0.76 | RET (0.35) | JAK2 | |
| SCHEMBL25374163 | 0.76 | TP53 (0.36) | — | |
| SCHEMBL3458495 | 0.76 | DHODH (0.40) | — | |
| SCHEMBL3459056 | 0.71 | APOBEC3A (0.49) | MAP4K4 | |
| SCHEMBL4127301 | 0.69 | HDAC2 (0.48) | HDAC2MAP4K4 | |
| SCHEMBL13127747 | 0.64 | MAP4K4 (0.32) | MAP4K4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592082-A1 | Heteroaryl amide analogues as p2x7 antagonists | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |