Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458365 | 0.80 | DHODH (0.36) | DHODHALDH1A1TDP1POLBL3MBTL1 | |
| SCHEMBL8886936 | 0.78 | DHODH (0.42) | DHODHALDH1A1L3MBTL1ALOX15RECQL | |
| SCHEMBL3460245 | 0.76 | DHODH (0.41) | DHODHALDH1A1TDP1POLBL3MBTL1 | |
| SCHEMBL14944141 | 0.76 | HDAC2 (0.36) | — | |
| SCHEMBL25372141 | 0.76 | ALDH1A1 (0.34) | ALDH1A1RECQLPDE4BKDM4EMAPT | |
| SCHEMBL25373902 | 0.76 | MAPK14 (0.33) | — | |
| SCHEMBL25373432 | 0.76 | PDE4B (0.36) | ALDH1A1TDP1PDE4B | |
| SCHEMBL18367335 | 0.75 | RET (0.35) | DHODHALDH1A1PARP1KDM4EHSD17B10 | |
| SCHEMBL25374163 | 0.72 | TP53 (0.36) | ALDH1A1TDP1POLBLMNAMAPT | |
| SCHEMBL25373360 | 0.72 | GAA (0.41) | ALDH1A1TDP1L3MBTL1PDE4BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140038955-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2014-02-06 | — | — | US | disclosed |
| US-8580812-B2 | Heteroaryl amide analogues as P2X7 antagonists | H. LUNDBECK A/S (DK) | 2013-11-12 | — | — | US | disclosed |
| EP-2592082-A1 | Heteroaryl amide analogues as p2x7 antagonists | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| EP-2592082-A1 | Heteroaryl amide analogues as p2x7 antagonists | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| US-20100266509-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. Lindbeck A/S (DK) | 2010-10-21 | — | — | US | disclosed |
| EP-2155744-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | Lundbeck, H., A/S (DK) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008124153-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100266509-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | P2RX7, P2RX3, P2RX2 | DHODH 3234/4885ALDH1A1 2338/4885TDP1 1995/4885 |
| US-20140038955-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | P2RX7, P2RX3, P2RX2 | DHODH 3303/4885ALDH1A1 2733/4885TDP1 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.