Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12756983 | 0.80 | APOBEC3A (0.49) | APOBEC3AAPOBEC3GSPRRPA1DHODH | |
| SCHEMBL29079139 | 0.80 | APOBEC3A (0.49) | APOBEC3AAPOBEC3GSPRRPA1DHODH | |
| SCHEMBL25372948 | 0.80 | APOBEC3A (0.49) | APOBEC3AAPOBEC3GSPRRPA1KMT2A | |
| SCHEMBL3460031 | 0.78 | SPR (0.47) | SPRALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL1665456 | 0.78 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GSPRRPA1DHODH | |
| SCHEMBL18372931 | 0.78 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GSPRRPA1DHODH | |
| Trifluoroacetic Acid SCHEMBL30680968 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1NPC1RAB9A | |
| SCHEMBL3461122 | 0.77 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GRPA1ALDH1A1KDM4E | |
| SCHEMBL22148137 | 0.76 | CA12 (0.46) | APOBEC3AAPOBEC3GSPRRPA1KDM4E | |
| SCHEMBL28410772 | 0.76 | APOBEC3A (0.45) | APOBEC3AAPOBEC3GSPRRPA1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140038955-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2014-02-06 | — | — | US | disclosed |
| US-8580812-B2 | Heteroaryl amide analogues as P2X7 antagonists | H. LUNDBECK A/S (DK) | 2013-11-12 | — | — | US | disclosed |
| EP-2592082-A1 | Heteroaryl amide analogues as p2x7 antagonists | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| US-20100266509-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. Lindbeck A/S (DK) | 2010-10-21 | — | — | US | disclosed |
| US-20040122782-A1 | Process for determining the composition of a dye product | L'OREAL (FR) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100266509-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | P2RX7, P2RX3, P2RX2 | APOBEC3A 1914/4885APOBEC3G 2268/4885SPR 3310/4885 |
| US-20140038955-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | P2RX7, P2RX3, P2RX2 | APOBEC3A 1954/4885APOBEC3G 2267/4885SPR 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.