Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263963 | 0.90 | L3MBTL1 (0.43) | NPC1RAB9AEPHX2PPARGEGLN1 | |
| SCHEMBL2266775 | 0.89 | ALDH1A1 (0.44) | NPC1RAB9AEPHX2PPARGCNR1 | |
| SCHEMBL2266394 | 0.88 | MTNR1A (0.43) | NPC1RAB9AEPHX2PPARGTP53 | |
| SCHEMBL2263299 | 0.85 | CNR1 (0.42) | NPC1RAB9AEPHX2PPARGEGLN1 | |
| SCHEMBL2262250 | 0.85 | EPHX2 (0.48) | EPHX2PPARGPOLBRXFP1GRIA1 | |
| SCHEMBL2263399 | 0.83 | PPARG (0.41) | EPHX2PPARGCNR1ITGB1ITGA4 | |
| SCHEMBL12390328 | 0.82 | CNR1 (0.44) | RAB9AEPHX2PPARGEGLN1CNR1 | |
| SCHEMBL2263570 | 0.81 | TP53 (0.43) | EPHX2PPARGTP53CNR1ITGB1 | |
| SCHEMBL12366594 | 0.77 | CNR1 (0.45) | RAB9APPARGCNR1RXFP1ITGB1 | |
| SCHEMBL12390365 | 0.77 | TP53 (0.40) | NPC1RAB9ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |