Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264362 | 0.87 | KDM4E (0.61) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL12390329 | 0.87 | RXRA (0.58) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL12390445 | 0.82 | RXRA (0.57) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL2263754 | 0.81 | KDM4E (0.61) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL14944219 | 0.80 | RXRA (0.55) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL2266794 | 0.78 | ALDH1A1 (0.55) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL11605720 | 0.74 | KDM4E (0.79) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL12366986 | 0.74 | RXRA (0.43) | KDM4EHPGDALDH1A1HSD17B10KMT2A | |
| SCHEMBL2265833 | 0.73 | KDM4E (0.55) | KDM4EHPGDPDE1CPDE9AALDH1A1 | |
| SCHEMBL11437715 | 0.73 | KDM4E (0.60) | KDM4EHPGDPDE1CPDE9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |