Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | TPH1 | P17752 | 2/20 | 0.37 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CD74 | P04233 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14944673 | 0.72 | TLR7 (0.64) | TLR7 | |
| SCHEMBL14944713 | 0.68 | ADORA1 (0.35) | TLR7HTT | |
| SCHEMBL14987126 | 0.68 | HTT (0.71) | ABHD6IDO1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL14944715 | 0.66 | TLR7 (0.41) | TLR7 | |
| SCHEMBL14944714 | 0.66 | TLR7 (0.44) | TLR7OPRD1ABHD6IDO1LOXL2 | |
| SCHEMBL23997296 | 0.65 | LMNA (0.53) | TLR7ABHD6IDO1LOXL2CYP4F2 | |
| SCHEMBL30345095 | 0.65 | LMNA (0.53) | TLR7ABHD6IDO1LOXL2CYP4F2 | |
| SCHEMBL6167291 | 0.64 | TP53 (0.62) | MAPTL3MBTL1 | |
| SCHEMBL21581161 | 0.64 | TLR7 (0.55) | TLR7 | |
| SCHEMBL20343835 | 0.63 | TLR7 (0.40) | TLR7OPRD1ABHD6IDO1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068438-A1 | PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN R&D IRELAND (IE) | 2013-05-16 | — | — | WO | disclosed |