Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 16/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14945687 | 0.91 | ADORA2B (0.58) | ADORA2BACACBACACAALDH1A1NPSR1 | |
| SCHEMBL14948733 | 0.87 | ACACB (0.61) | ADORA2BACACBACACAALDH1A1NPSR1 | |
| SCHEMBL14945669 | 0.87 | ADORA2B (0.52) | ADORA2BACACBACACALMNA | |
| SCHEMBL14945672 | 0.82 | ADORA2B (0.44) | ADORA2BACACBACACAALDH1A1NPSR1 | |
| SCHEMBL14945691 | 0.82 | ADORA2B (0.56) | ADORA2BACACBACACAALDH1A1NPSR1 | |
| SCHEMBL14945694 | 0.79 | ADORA2B (0.54) | ADORA2BACACBACACAALDH1A1NPSR1 | |
| SCHEMBL14945688 | 0.79 | ADORA2B (0.69) | ADORA2BACACBACACALMNA | |
| SCHEMBL14944951 | 0.78 | ACACB (0.74) | ADORA2BACACBACACALMNA | |
| SCHEMBL14945689 | 0.77 | ADORA2B (0.70) | ADORA2BACACBACACALMNA | |
| SCHEMBL14945491 | 0.77 | ADORA2B (0.54) | ADORA2BACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944655-B2 | ACC inhibitors and uses thereof | GILEAD APOLLO, LLC (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160297834-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC | 2016-10-13 | — | — | US | disclosed |
| US-20150203510-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC | 2015-07-23 | — | — | US | disclosed |
| US-8969557-B2 | ACC inhibitors and uses thereof | Nimbus Apollo, Inc. (US) | 2015-03-03 | — | — | US | disclosed |
| US-20130123231-A1 | ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. (US) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203510-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | ADORA2B 3395/4885ACACB 2/4885ACACA 1/4885 |
| US-20130123231-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | ADORA2B 3395/4885ACACB 2/4885ACACA 1/4885 |
| US-20160297834-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | ADORA2B 3395/4885ACACB 2/4885ACACA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.