Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.69 |
| ▸ | APEX1 | P27695 | 9/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13833618 | 0.88 | APEX1 (0.80) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL3753082 | 0.83 | APEX1 (0.69) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL13812574 | 0.82 | APEX1 (0.74) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL13735042 | 0.82 | APEX1 (1.00) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL13833621 | 0.81 | APEX1 (0.80) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL3757868 | 0.80 | APEX1 (0.70) | UHRF1APEX1LMNATP53RXFP1 | |
| Hydrochloric Acid SCHEMBL18953084 | 0.80 | APEX1 (0.70) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL14209373 | 0.80 | APEX1 (0.67) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL1292581 | 0.80 | APEX1 (0.67) | UHRF1APEX1LMNATP53RXFP1 | |
| SCHEMBL3746867 | 0.80 | APEX1 (0.75) | UHRF1APEX1LMNATP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053915-A1 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM | ALLA CHEM, LLC (US) | 2011-03-03 | — | — | US | claimed |
| US-20100298370-A1 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD. (IL) | 2010-11-25 | — | — | US | claimed |
| WO-2008020438-A2 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD (IL) | 2008-02-21 | — | — | WO | claimed |
| US-8486945-B2 | Heterocyclic inhibitors of an Hh-signal cascade, medicinal compositions based thereon and methods for treating diseases caused by the aberrant activity of an Hh-signal system | Ivachtchenko, Alexandre Vasilievich (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486945-B2 | Heterocyclic inhibitors of an Hh-signal cascade, medicinal compositions based thereon and methods for treating diseases caused by the aberrant activity of an Hh-signal system | Ivachtchenko, Alexandre Vasilievich (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110053915-A1 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM | ALLA CHEM, LLC (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053915-A1 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM | ALLA CHEM, LLC (US) | 2011-03-03 | — | — | US | disclosed |
| US-20100298370-A1 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD. (IL) | 2010-11-25 | — | — | US | disclosed |
| US-20100298370-A1 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD. (IL) | 2010-11-25 | — | — | US | disclosed |
| WO-2009077956-A2 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM | ALLA CHEM, LLC (US) | 2009-06-25 | — | — | WO | disclosed |
| WO-2008020438-A2 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD (IL) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008020438-A2 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD (IL) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298370-A1 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | HPSE, HDGF, HPGDS | UHRF1 4279/4885APEX1 4756/4885LMNA 4715/4885 |
| US-20110053915-A1 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM | SHH, SMO, GLI1 | UHRF1 1139/4885APEX1 4588/4885LMNA 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.