Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 4/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.39 |
| ▸ | EIF4E | P06730 | 2/20 | 0.39 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.39 |
| ▸ | KRAS | P01116 | 2/20 | 0.39 |
| ▸ | TCF4 | P15884 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14948248 | 1.00 | ESR1 (0.40) | ESR1MCL1PCSK9MDM4MDM2 | |
| SCHEMBL16975610 | 0.90 | MDM4 (0.43) | ESR1MCL1PCSK9MDM4MDM2 | |
| SCHEMBL14947855 | 0.89 | MCL1 (0.47) | ESR1MCL1PCSK9MDM4MDM2 | |
| SCHEMBL14947860 | 0.88 | MDM4 (0.43) | ESR1MCL1MDM4MDM2EIF4E | |
| SCHEMBL14950915 | 0.82 | EIF4E (0.38) | ESR1MCL1PCSK9MDM4MDM2 | |
| SCHEMBL16975819 | 0.82 | ESR1 (0.34) | ESR1MCL1PCSK9MDM4MDM2 | |
| SCHEMBL16975828 | 0.82 | ESR1 (0.34) | ESR1MCL1PCSK9MDM4MDM2 | |
| SCHEMBL12297508 | 0.76 | MDM2 (0.58) | ESR1PCSK9MDM4MDM2EIF4E | |
| SCHEMBL12581072 | 0.71 | MDM2 (0.68) | PCSK9MDM4MDM2KRASEED | |
| SCHEMBL14648779 | 0.68 | MDM2 (0.52) | ESR1PCSK9MDM4MDM2CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096684-B2 | Peptidomimetic macrocycles | AILERON THERAPEUTICS, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20130123169-A1 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123169-A1 | PEPTIDOMIMETIC MACROCYCLES | GHRHR, GHSR, GHITM | ESR1 470/4885MCL1 677/4885PCSK9 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.