Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949185

SCHEMBL14949185

SCHEMBL14949185

Cc1cccc(Nc2nnc(-c3ccc(Oc4ccnc(Cl)c4)cc3)[nH]2)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 8/20 0.37
▸ FLT1 P17948 3/20 0.37
▸ PIK3CA P42336 2/20 0.36
▸ PIK3CG P48736 2/20 0.36
▸ TTBK1 Q5TCY1 1/20 0.35
▸ TTBK2 Q6IQ55 1/20 0.35
▸ RAF1 P04049 3/20 0.35
▸ BRAF P15056 2/20 0.35
▸ NFKB1 P19838 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ PIK3CB P42338 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ BCR P11274 1/20 0.34
▸ CDK8 P49336 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949190 0.90 KDR (0.38) KDRFLT1PIK3CAPIK3CGTTBK1
SCHEMBL14949182 0.88 KDR (0.41) KDRFLT1PIK3CAPIK3CGTTBK1
SCHEMBL14949198 0.88 KDR (0.39) KDRFLT1PIK3CAPIK3CGTTBK1
SCHEMBL14949184 0.87 KMT2A (0.42) KDRFLT1RAF1TP53MAPT
SCHEMBL12336724 0.85 BRAF (0.47) KDRFLT1RAF1BRAFHTT
SCHEMBL14949183 0.85 PIK3CA (0.38) KDRPIK3CAPIK3CGNFKB1TP53
SCHEMBL12336405 0.84 P2RX3 (0.41) KDRRAF1BRAFABL1
SCHEMBL14949267 0.82 PIK3CA (0.38) KDRFLT1PIK3CAPIK3CGTP53
SCHEMBL14949365 0.81 ABL1 (0.37) KDRFLT1PIK3CAPIK3CGTTBK1
SCHEMBL14949317 0.81 KMT2A (0.40) KDRFLT1TTBK1TTBK2RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 KDR 533/4885FLT1 977/4885PIK3CA 215/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885FLT1 977/4885PIK3CA 215/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885FLT1 977/4885PIK3CA 215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.