Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949183

SCHEMBL14949183

SCHEMBL14949183

Cc1cccc(Nc2nnc(-c3ccc(Oc4cc(Cl)ccn4)cc3)[nH]2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CA P42336 2/20 0.38
▸ PIK3CG P48736 2/20 0.38
▸ PIK3CB P42338 1/20 0.38
▸ ABL1 P00519 5/20 0.36
▸ EGFR P00533 4/20 0.36
▸ SRC P12931 1/20 0.36
▸ PRKCA P17252 1/20 0.36
▸ MAPT P10636 3/20 0.36
▸ TP53 P04637 2/20 0.36
▸ DRD1 P21728 1/20 0.36
▸ KDR P35968 1/20 0.36
▸ TNNI3K Q59H18 1/20 0.36
▸ KMT2A Q03164 2/20 0.35
▸ NFKB1 P19838 1/20 0.34
▸ ABL2 P42684 2/20 0.34
▸ GRM4 Q14833 1/20 0.34
▸ MAPK14 Q16539 1/20 0.34
▸ FADS1 O60427 1/20 0.34
▸ DHODH Q02127 1/20 0.34
▸ BCR P11274 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12336729 0.85 PDGFRB (0.43) EGFRKDRTNNI3KMAPK14HTT
SCHEMBL14949198 0.85 KDR (0.39) PIK3CAPIK3CGPIK3CBMAPTTP53
SCHEMBL14949185 0.85 KDR (0.37) PIK3CAPIK3CGPIK3CBABL1MAPT
SCHEMBL14949267 0.85 PIK3CA (0.38) PIK3CAPIK3CGPIK3CBABL1SRC
SCHEMBL14949277 0.84 KDR (0.43) ABL1EGFRMAPTTP53KDR
SCHEMBL14949256 0.83 ROCK1 (0.39) PIK3CAPIK3CGABL1EGFRKDR
SCHEMBL14949219 0.83 KDR (0.44) PIK3CAPIK3CGPIK3CBKDR
SCHEMBL14949190 0.82 KDR (0.38) PIK3CAPIK3CGABL1MAPTTP53
SCHEMBL14949271 0.82 PIK3CG (0.39) PIK3CAPIK3CGPIK3CBABL1EGFR
SCHEMBL14949257 0.82 KDR (0.42) ABL1EGFRMAPTKDRTNNI3K

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 PIK3CA 215/4885PIK3CG 333/4885PIK3CB 150/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PIK3CA 215/4885PIK3CG 333/4885PIK3CB 150/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PIK3CA 215/4885PIK3CG 333/4885PIK3CB 150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.