Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949267

SCHEMBL14949267

SCHEMBL14949267

Cc1cccc(Nc2nnc(-c3ccc(Oc4ccnc(C)n4)cc3)[nH]2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CA P42336 2/20 0.38
▸ PIK3CG P48736 2/20 0.38
▸ KDR P35968 6/20 0.36
▸ ABL1 P00519 1/20 0.36
▸ BCR P11274 1/20 0.36
▸ MAPT P10636 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ ADORA2A P29274 1/20 0.34
▸ TNNI3K Q59H18 1/20 0.34
▸ DHODH Q02127 1/20 0.34
▸ MET P08581 1/20 0.34
▸ PIK3CB P42338 1/20 0.34
▸ FLT1 P17948 2/20 0.34
▸ FLT4 P35916 2/20 0.34
▸ FGFR1 P11362 1/20 0.34
▸ FLT3 P36888 1/20 0.34
▸ MERTK Q12866 1/20 0.34
▸ NTRK2 Q16620 1/20 0.34
▸ KMT2A Q03164 2/20 0.33
▸ MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949322 0.91 ABL1 (0.38) PIK3CAPIK3CGKDRABL1BCR
SCHEMBL14949256 0.90 ROCK1 (0.39) PIK3CAPIK3CGKDRABL1BCR
SCHEMBL16786029 0.90 PIK3CA (0.37) PIK3CAPIK3CGKDRABL1BCR
SCHEMBL14949271 0.89 PIK3CG (0.39) PIK3CAPIK3CGKDRABL1BCR
SCHEMBL12336248 0.88 KDR (0.47) KDRTNNI3KFLT1FLT4FLT3
SCHEMBL14949258 0.85 PDGFRB (0.43) KDRABL1MAPTTP53ADORA2A
SCHEMBL14949183 0.85 PIK3CA (0.38) PIK3CAPIK3CGKDRABL1BCR
SCHEMBL14949198 0.84 KDR (0.39) PIK3CAPIK3CGKDRMAPTTP53
SCHEMBL14949190 0.83 KDR (0.38) PIK3CAPIK3CGKDRABL1BCR
SCHEMBL16786026 0.83 KDR (0.33) PIK3CAPIK3CGKDRABL1BCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 PIK3CA 215/4885PIK3CG 333/4885KDR 533/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PIK3CA 215/4885PIK3CG 333/4885KDR 533/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PIK3CA 215/4885PIK3CG 333/4885KDR 533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.