Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949271

SCHEMBL14949271

SCHEMBL14949271

COc1nccc(Oc2ccc(-c3nnc(Nc4cccc(C)c4)[nH]3)cc2)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CG P48736 5/20 0.39
▸ PIK3CA P42336 4/20 0.39
▸ PIK3CB P42338 3/20 0.39
▸ KMT2A Q03164 3/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ ALOX15 P16050 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ KDR P35968 3/20 0.35
▸ AKR1C3 P42330 1/20 0.35
▸ AKR1C2 P52895 1/20 0.35
▸ CDK5 Q00535 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ P2RX3 P56373 1/20 0.35
▸ EGFR P00533 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ BCR P11274 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949339 0.91 SYK (0.38) PIK3CGPIK3CAPIK3CBKMT2AMEN1
SCHEMBL14949267 0.89 PIK3CA (0.38) PIK3CGPIK3CAPIK3CBKMT2AMEN1
SCHEMBL14949256 0.87 ROCK1 (0.39) PIK3CGPIK3CAKMT2AMEN1KDR
SCHEMBL12336274 0.87 BRAF (0.45) LMNAKDRAKR1C3AKR1C2PDGFRA
SCHEMBL14949696 0.86 PDGFRB (0.41) KMT2AMEN1LMNAALOX15TSHR
SCHEMBL14949198 0.85 KDR (0.39) PIK3CGPIK3CAPIK3CBKMT2AKDR
SCHEMBL14949277 0.84 KDR (0.43) KMT2AMEN1LMNATSHRHSD17B10
SCHEMBL14949183 0.82 PIK3CA (0.38) PIK3CGPIK3CAPIK3CBKMT2AMEN1
SCHEMBL14949378 0.82 SYK (0.37) PIK3CGPIK3CAKMT2AMEN1TSHR
SCHEMBL14949375 0.82 GSK3B (0.37) PIK3CGPIK3CAPIK3CBKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 PIK3CG 333/4885PIK3CA 215/4885PIK3CB 150/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PIK3CG 333/4885PIK3CA 215/4885PIK3CB 150/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PIK3CG 333/4885PIK3CA 215/4885PIK3CB 150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.