Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949256

SCHEMBL14949256

SCHEMBL14949256

Cc1cccc(Nc2nnc(-c3ccc(Oc4ccnc(N)n4)cc3)[nH]2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ROCK1 Q13464 4/20 0.39
▸ KDR P35968 5/20 0.37
▸ PIK3CA P42336 1/20 0.37
▸ PIK3CG P48736 1/20 0.37
▸ ROCK2 O75116 1/20 0.37
▸ PRKACA P17612 1/20 0.37
▸ PRKCD Q05655 1/20 0.37
▸ DYRK1A Q13627 1/20 0.37
▸ CDC42BPA Q5VT25 1/20 0.37
▸ EGFR P00533 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ RECQL P46063 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ PDGFRB P09619 2/20 0.36
▸ KIT P10721 2/20 0.36
▸ RET P07949 1/20 0.36
▸ FLT1 P17948 1/20 0.36
▸ FLT4 P35916 1/20 0.36
▸ CDK5 Q00535 1/20 0.35
▸ PDGFRA P16234 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949309 0.91 ROCK1 (0.40) ROCK1KDRPIK3CAPIK3CGROCK2
SCHEMBL14949267 0.90 PIK3CA (0.38) KDRPIK3CAPIK3CGMEN1KMT2A
SCHEMBL14949271 0.87 PIK3CG (0.39) ROCK1KDRPIK3CAPIK3CGEGFR
SCHEMBL17658744 0.86 ROCK1 (0.39) ROCK1KDRPIK3CAPIK3CGEGFR
SCHEMBL14949279 0.86 PDGFRB (0.37) KDREGFRMEN1KMT2APDGFRB
SCHEMBL12336512 0.86 KDR (0.51) KDRPDGFRBKITRETFLT1
SCHEMBL14949247 0.86 RAB9A (0.37) KDREGFRMEN1RECQLKMT2A
SCHEMBL14949182 0.84 KDR (0.41) KDRPIK3CAPIK3CGEGFRFLT1
SCHEMBL14949288 0.84 RAB9A (0.39) MEN1RECQLKMT2APDGFRBKIT
SCHEMBL14949260 0.83 KIT (0.37) KDREGFRMEN1RECQLKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 ROCK1 488/4885KDR 533/4885PIK3CA 215/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 ROCK1 488/4885KDR 533/4885PIK3CA 215/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 ROCK1 488/4885KDR 533/4885PIK3CA 215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.