Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9966080 | 0.85 | ALDH1A1 (0.48) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL1594145 | 0.85 | ALDH1A1 (0.48) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL1594222 | 0.83 | ALDH1A1 (0.47) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL1594835 | 0.83 | ALDH1A1 (0.46) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL15905581 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL1594036 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL13008472 | 0.81 | ALDH1A1 (0.46) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL1593798 | 0.77 | ALDH1A1 (0.59) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL12620551 | 0.76 | ALDH1A1 (0.55) | ALDH1A1GAAL3MBTL1POLBPTGES2 | |
| SCHEMBL4244410 | 0.74 | ALDH1A1 (0.53) | ALDH1A1GAAL3MBTL1POLBPTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2465850-B1 | THERAPEUTIC COMPOUNDS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2016-11-23 | — | — | EP | disclosed |
| EP-1989185-B1 | THERAPEUTIC COMPOUNDS | HELICON THERAPEUTICS INC (US) | 2013-05-22 | — | — | EP | disclosed |