Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | MGAM | O43451 | 3/20 | 0.48 |
| ▸ | SI | P14410 | 3/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14958588 | 0.86 | CNR2 (0.52) | GAAPARP1CNR2MEN1POLB | |
| SCHEMBL14958590 | 0.86 | MGAM (0.50) | GAAMGAMSIMGAM2CLK2 | |
| SCHEMBL14958589 | 0.81 | GAA (0.51) | GAAMGAMSIMGAM2CLK2 | |
| SCHEMBL712492 | 0.80 | MGAM (0.55) | GAAMGAMSIMGAM2CLK2 | |
| SCHEMBL17300893 | 0.78 | GAA (0.46) | GAAMGAMSIMGAM2PARP1 | |
| SCHEMBL10248490 | 0.73 | MEN1 (0.53) | GAAPARP1MEN1POLBMAPT | |
| SCHEMBL6759197 | 0.73 | MGAM (0.50) | GAAMGAMSIMGAM2PARP1 | |
| SCHEMBL19000985 | 0.73 | L3MBTL1 (0.47) | GAAPARP1MEN1POLBMAPT | |
| SCHEMBL18672684 | 0.72 | ALDH1A1 (0.51) | GAAPARP1MEN1POLBMAPT | |
| SCHEMBL3968507 | 0.71 | PARP1 (0.44) | GAAPARP1MEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445473-B2 | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-05-21 | — | — | US | disclosed |