Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | SI | P14410 | 3/20 | 0.55 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.55 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 6/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17263813 | 0.87 | PARP1 (0.47) | MGAMGAASIMGAM2DHODH | |
| SCHEMBL10696507 | 0.85 | CNR2 (0.49) | MGAMGAASIMGAM2DHODH | |
| SCHEMBL14959119 | 0.84 | MGAM (0.57) | MGAMGAASIMGAM2CLK2 | |
| SCHEMBL20936149 | 0.82 | PARP1 (0.56) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL14958587 | 0.80 | GAA (0.48) | MGAMGAASIMGAM2CLK2 | |
| SCHEMBL8589063 | 0.79 | PARP1 (0.48) | MGAMGAASIMGAM2DHODH | |
| SCHEMBL14959118 | 0.79 | MGAM (0.59) | MGAMGAASIMGAM2CLK2 | |
| SCHEMBL14162137 | 0.77 | DHODH (0.41) | MGAMGAASIMGAM2DHODH | |
| SCHEMBL29967926 | 0.76 | PTGS2 (0.41) | DHODHPARP1CNR2 | |
| SCHEMBL1902643 | 0.75 | PARP1 (0.53) | MGAMGAASIMGAM2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445473-B2 | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-05-21 | — | — | US | disclosed |
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |