Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690643 | 0.88 | CDK1 (0.49) | SYKBRD4EGFRTUBB4ATUBB | |
| SCHEMBL691488 | 0.87 | CDK1 (0.48) | SYKBRD4EGFRTUBB4ATUBB | |
| SCHEMBL12388686 | 0.85 | EGFR (0.50) | THRBSYKBRD4EGFRTUBB4A | |
| SCHEMBL19890987 | 0.84 | L3MBTL1 (0.44) | THRBMAP4K4 | |
| SCHEMBL13148498 | 0.82 | EGFR (0.45) | SYKBRD4EGFRTUBB4ATUBB | |
| SCHEMBL13148414 | 0.80 | KDR (0.53) | KDR | |
| SCHEMBL691467 | 0.80 | EGFR (0.47) | SYKBRD4EGFRTUBB4ATUBB | |
| SCHEMBL29029431 | 0.80 | HDAC3 (0.56) | SYKBRD4CYP17A1LMNAMAPT | |
| SCHEMBL2205381 | 0.79 | EGFR (0.52) | SYKEGFRTUBB4ATUBBTUBA3C | |
| SCHEMBL6869447 | 0.77 | LMNA (0.51) | SYKBRD4CYP17A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445498-B2 | 4,6-disubstituted pyrimidines useful as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2013-05-21 | — | — | US | disclosed |