Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.42 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.42 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.42 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.42 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.42 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.42 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.42 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12277365 | 0.83 | HSD11B1 (0.46) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL27800423 | 0.82 | KDM4E (0.45) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL14960645 | 0.81 | DYRK1A (0.49) | KCNH2SCN10AHSD11B1 | |
| SCHEMBL14675684 | 0.81 | CLK4 (0.48) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL7845612 | 0.79 | KIF11 (0.47) | KDM4EGAAMAPTTDP2KCNH2 | |
| SCHEMBL3462133 | 0.77 | HDAC4 (0.46) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL10194263 | 0.76 | KDM4E (0.51) | KDM4ENPC1ALDH1A1GAARAB9A | |
| SCHEMBL23407635 | 0.76 | GRM2 (0.45) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL10227692 | 0.74 | HDAC4 (0.42) | KDM4ENPC1GAARAB9ATDP2 | |
| SCHEMBL10176272 | 0.74 | KIF11 (0.47) | KDM4ENPC1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-05-07 | — | — | US | disclosed |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8445503-B2 | Inhibitors of polo-like kinase | ELAN PHARMACEUTICALS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | PLK1, POLK, POLR2E | KDM4E 1910/4885NPC1 2988/4885ALDH1A1 4226/4885 |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | KDM4E 1953/4885NPC1 2992/4885ALDH1A1 4256/4885 |
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | KDM4E 1953/4885NPC1 2992/4885ALDH1A1 4256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.