SCHEMBL14964014

SCHEMBL14964014

Cc1cc2c(-c3cccc4ccccc34)c3sc(C)cc3c(-c3ccc(-c4cccc5ccccc45)cc3)c2s1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 1/20 0.43
ENPP1 P22413 1/20 0.43
CA12 O43570 5/20 0.41
CA1 P00915 5/20 0.41
CA2 P00918 5/20 0.41
CA9 Q16790 5/20 0.41
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
DHFR P00374 1/20 0.38
PPARG P37231 7/20 0.37
PPARA Q07869 7/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
PPARD Q03181 1/20 0.37
PRKDC P78527 1/20 0.37
MCL1 Q07820 1/20 0.37
ACMSD Q8TDX5 1/20 0.37
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA7 P36544 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14964009 0.93 DHFR (0.39) ENPP3ENPP1CA12CA1CA2
SCHEMBL14964003 0.91 DHFR (0.44) ENPP3ENPP1CA12CA1CA2
SCHEMBL14964007 0.84 HPRT1 (0.44) DHFRCYP2C9CYP2C19
SCHEMBL14964008 0.82 GPR84 (0.38) HDAC8CYP2C9CYP2C19MAPK14
SCHEMBL10054160 0.82 PPARG (0.40) ENPP3ENPP1CA12CA1CA2
SCHEMBL14964019 0.79 ALDH1A1 (0.42) MAPK14
SCHEMBL14964021 0.78 ALDH1A1 (0.41) MAPK14
SCHEMBL14964002 0.76 CHEK1 (0.38) PPARG
SCHEMBL14964011 0.75 IKBKB (0.43) HDAC8CYP2C9CYP2C19MAPK14
SCHEMBL10054165 0.75 KCNQ3 (0.37) ENPP1CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9394406-B2 Polymers containing substituted benzodithiophene units, blends comprising these polymers, and devices comprising these polymers or blends MERCK PATENT GMBH (DE) 2016-07-19 US disclosed
US-20130126855-A1 POLYMERS CONTAINING SUBSTITUTED BENZODITHIOPHENE UNITS, BLENDS COMPRISING THESE POLYMERS, AND DEVICES COMPRISING THESE POLYMERS OR BLENDS MERCK PATENT GMBH (DE) 2013-05-23 US disclosed