Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 5/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15093027 | 0.83 | MAPT (0.36) | ALDH1A1SMN1; SMN2USP2IDO1TDO2 | |
| SCHEMBL15093214 | 0.82 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2USP2LMNAIDO1 | |
| SCHEMBL14462370 | 0.82 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL14964338 | 0.82 | IDO1 (0.35) | ALDH1A1SMN1; SMN2IDO1TDO2MEN1 | |
| SCHEMBL14964328 | 0.81 | IDO1 (0.37) | ALDH1A1SMN1; SMN2IDO1TDO2 | |
| SCHEMBL14964252 | 0.80 | IDO1 (0.45) | ALDH1A1SMN1; SMN2USP2LMNAIDO1 | |
| SCHEMBL14964214 | 0.79 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2LMNAIDO1TDO2 | |
| SCHEMBL14964354 | 0.78 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2USP2LMNAIDO1 | |
| SCHEMBL14964272 | 0.78 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2USP2LMNAIDO1 | |
| SCHEMBL14964308 | 0.78 | IDO1 (0.33) | ALDH1A1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |