Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 7/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979731 | 0.89 | IDO1 (0.34) | ALDH1A1IDO1TDO2L3MBTL1LMNA | |
| SCHEMBL14964279 | 0.85 | IDO1 (0.33) | IDO1TDO2 | |
| SCHEMBL4980217 | 0.84 | TAAR1 (0.35) | ALDH1A1IDO1TDO2SMN1; SMN2KDM4E | |
| SCHEMBL16435132 | 0.84 | MCHR1 (0.33) | IDO1POLBMCHR1 | |
| SCHEMBL14964194 | 0.83 | SMN1; SMN2 (0.37) | ALDH1A1IDO1TDO2POLBSMN1; SMN2 | |
| SCHEMBL14462356 | 0.83 | SMN1; SMN2 (0.40) | ALDH1A1EGFRSMN1; SMN2KDM4EGAA | |
| Trifluoroacetic Acid SCHEMBL15093526 | 0.83 | IDO1 (0.32) | ALDH1A1IDO1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL4971385 | 0.82 | ALDH1A1 (0.38) | ALDH1A1IDO1TDO2POLBSMN1; SMN2 | |
| SCHEMBL14964340 | 0.82 | SIGMAR1 (0.36) | ALDH1A1IDO1SMN1; SMN2KDM4EGAA | |
| SCHEMBL15093527 | 0.82 | MAPT (0.32) | ALDH1A1IDO1SMN1; SMN2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |