Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971385 | 0.90 | ALDH1A1 (0.38) | IDO1ALDH1A1TDO2MEN1LMNA | |
| SCHEMBL14964244 | 0.87 | ALDH1A1 (0.36) | IDO1ALDH1A1RORCMEN1LMNA | |
| SCHEMBL14964354 | 0.85 | ALDH1A1 (0.39) | IDO1ALDH1A1TDO2MEN1LMNA | |
| SCHEMBL14964272 | 0.84 | ALDH1A1 (0.35) | IDO1ALDH1A1RORCMEN1LMNA | |
| SCHEMBL14964369 | 0.84 | ALDH1A1 (0.36) | IDO1ALDH1A1TDO2MEN1LMNA | |
| SCHEMBL14964325 | 0.83 | IDO1 (0.35) | IDO1ALDH1A1TDO2RORCMEN1 | |
| SCHEMBL14462043 | 0.83 | SMN1; SMN2 (0.39) | IDO1RORCMEN1LMNAKMT2A | |
| SCHEMBL14964280 | 0.80 | MAPT (0.46) | ALDH1A1RORCMEN1LMNATP53 | |
| SCHEMBL14964252 | 0.79 | IDO1 (0.45) | IDO1ALDH1A1MEN1LMNATP53 | |
| Trifluoroacetic Acid SCHEMBL15093526 | 0.79 | IDO1 (0.32) | IDO1ALDH1A1MEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |